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Selected Publications


  1. Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets.
    Hartmans, E.; Orian-Rousseau, V.; Matzke-Ogi, A.; Karrenbeld, A.; de Groot, D. J. A.; de Jong, S.; van Dam, G. M.; Fehrmann, R. S. N.; Nagengast, W. B.
    2017. Theranostics, 7 (2), 482–492. doi:10.7150/thno.16816
  2. A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer.
    Preca, B.-T.; Bajdak, K.; Mock, K.; Lehmann, W.; Sundararajan, V.; Bronsert, P.; Matzge-Ogi, A.; Orian-Rousseau, V.; Brabletz, S.; Brabletz, T.; Maurer, J.; Stemmler, M. P.
    2017. OncoTarget, 8 (7), 11530-11543. doi:10.18632/oncotarget.14563
  3. CD44v6-Peptide Functionalized Nanoparticles Selectively Bind to Metastatic Cancer Cells.
    Li, L.; Schmitt, M.; Matzke-Ogi, A.; Wadhwani, P.; Orian-Rousseau, V.; Levkin, P. A.
    2017. Advanced science, 4 (1), 1600202/1-9. doi:10.1002/advs.201600202
  4. CD44 mediates the catch-bond activated rolling of HEPG2Iso epithelial cancer cells on hyaluronan [in press].
    Hanke-Roos, M.; Fuchs, K.; Maleschlijski, S.; Sleeman, J.; Orian-Rousseau, V.; Rosenhahn, A.
    2016. Cell adhesion & migration, 1–12. doi:10.1080/19336918.2016.1260809
  5. CD44: More than a mere stem cell marker.
    Morath, I.; Hartmann, T. N.; Orian-Rousseau, V.
    2016. International journal of biochemistry & cell biology, 81, 166-173. doi:10.1016/j.biocel.2016.09.009
  6. Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.
    Shatirishvili, M.; Burk, A. S.; Franz, C. M.; Pace, G.; Kastilan, T.; Breuhahn, K.; Hinterseer, E.; Dierich, A.; Bakiri, L.; Wagner, E. F.; Ponta, H.; Hartmann, T. N.; Tanaka, M.; Orian-Rousseau, V.
    2016. Cell death & disease, 7, Article no: e2461. doi:10.1038/cddis.2016.342
  7. Live cell imaging shows hepatocyte growth factor-induced Met dimerization.
    Koschut, D.; Richert, L.; Pace, G.; Niemann, H. H.; Mely, Y.; Orian-Rousseau, V.
    2016. Biochimica et Biophysica Acta - Molecular Cell Research, 1863 (7), 1552-1558. doi:10.1016/j.bbamcr.2016.04.015
  8. Fighting pancreatic cancer.
    Orian-Rousseau, V.
    2016. Pan European Networks: Science and Technology, 18, 192-193
  9. Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference with CD44v6 Signaling.
    Matzke-Ogi, A.; Jannasch, K.; Shatirishvili, M.; Fuchs, B.; Chiblak, S.; Morton, J.; Tawk, B.; Lindner, T.; Sansom, O.; Alves, F.; Warth, A.; Schwager, C.; Mier, W.; Kleeff, J.; Ponta, H.; Abdollahi, A.; Orian-Rousseau, V.
    2016. Gastroenterology, 150 (2), 513-525e10. doi:10.1053/j.gastro.2015.10.020
  10. Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6.
    Volz, Y.; Koschut, D.; Matzke-Ogi, A.; Dietz, M. S.; Karathanasis, C.; Richert, L.; Wagner, M. G.; Mély, Y.; Heilemann, M.; Niemann, H. H.; Orian-Rousseau, V.
    2015. Bioscience reports, 35 (4), e00236. doi:10.1042/BSR20150093
  11. CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation.
    Bertaux-Skeirik, N.; Feng, R.; Schumacher, M. A.; Li, J.; Mahe, M. M.; Engevik, A. C.; Javier, J. E.; Peek, R. M.; Ottemann, K.; Orian-Rousseau, V.; Boivin, G. P.; Helmrath, M. A.; Zavros, Y.
    2015. PLoS Pathogens, 11 (2), 1-24/e1004663. doi:10.1371/journal.ppat.1004663
  12. Paracrine met signaling triggers epithelial mesenchymal transition in mammary luminal progenitors, affecting their fate.
    Di-Cicco, A.; Petit, V.; Chiche, A.; Bresson, L.; Romagnoli, M.; Orian-Rousseau, V.; Vivanco, M.; Medina, D.; Faraldo, M. M.; Glukhova, M. A.; Deugnier, M. A.
    2015. eLife, 4, e06104/1-25. doi:10.7554/eLife.06104
  13. Perspectives of CD44 targeting therapies.
    Orian-Rousseau, V.; Ponta, H.
    2015. Archives of Toxicology, 89, 3-14. doi:10.1007/s00204-014-1424-2
  14. CD44 acts as a signaling platform controlling tumor progression and metastasis.
    Orian-Rousseau, V.
    2015. Frontiers in immunology, 6 (154), 1-4. doi:10.3389/fimmu.2015.00154
  15. CD44 functions in Wnt signaling by regulating LRP6 localization and activation.
    Schmitt, M.; Metzger, M.; Gradl, D.; Davidson, G.; Orian-Rousseau, V.
    2015. Cell Death and Differentiation, 22, 677-689. doi:10.1038/cdd.2014.156
  16. CD44 is a multidomain signaling platform that integrates extracellular matrix cues with growth factor and cytokine signals.
    Orian-Rousseau, V.; Sleeman, J.
    2014. Advances in Cancer Research, 123, 231-254. doi:10.1016/B978-0-12-800092-2.00009-5
  17. Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling.
    Rengarajan, C.; Matzke, A.; Reiner, L.; Orian-Rousseau, V.; Scholpp, S.
    2014. PLOS ONE, 9 (1), e86373/1-11. doi:10.1371/journal.pone.0086373
  18. Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins.
    Hasenauer, S.; Malinger, D.; Koschut, D.; Pace, G.; Matzke, A.; Au, A. von; Orian-Rousseau, V.
    2013. PLoS one, 8 (4), e62357/1-15. doi:10.1371/journal.pone.0062357
  19. Opposing effects of high- and low-molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44.
    Fuchs, K.; Hippe, A.; Schmaus, A.; Homey, B.; Sleeman, J. P.; Orian-Rousseau, V.
    2013. Cell death & disease, 4, Art. Nr. e819. doi:10.1038/cddis.2013.364
  20. The surface proteins InlA and InlB are interdependently required for polar basolateral invasion by Listeria monocytogenes in a human model of the blood-cerebrospinal fluid barrier.
    Gründler, T.; Quednau, N.; Stump, C.; Orian-Rousseau, V.; Ishikawa, H.; Wolburg, H.; Schroten, H.; Tenenbaum, T.; Schwerk, C.
    2013. Microbes and Infection, 15, 291-01. doi:10.1016/j.micinf.2012.12.005
  21. Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis.
    Meinecke, A. K.; Nagy, N.; D'Amico Lago, G.; Kirmse, S.; Klose, R.; Schrödter, K.; Zimmermann, A.; Helfrich, I.; Rundqvist, H.; Theegarten, D.; Anhenn, O.; Orian-Rousseau, V.; Johnson, R. S.; Alitalo, K.; Fischer, J. W.; Fandrey, J.; Stockmann, C.
    2012. Blood, 119, 5931-5942. doi:10.1182/blood-2011-12-396895
  22. c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null mice.
    Olaku, V.; Matzke, A.; Mitchell, C.; Hasenauer, S.; Sakkaravarthi, A.; Pace, G.; Ponta, H.; Orian-Rousseau, V.
    2011. Molecular Biology of the Cell, 22, 2777-2786. doi:10.1091/mbc.E11-02-0134
  23. CD44, a therapeutic target for metastasising tumours.
    Orian-Rousseau, V.
    2010. European Journal of Cancer, 46, 1271-77. doi:10.1016/j.ejca.2010.02.024
  24. A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis.
    Tremmel, M.; Matzke, A.; Albrecht, I.; Laib, A. M.; Olaku, V.; Ballmer-Hofer, K.; Christofori, G.; Heroult, M.; Augustin, H. G.; Ponta, H.; Orian-Rousseau, V.
    2009. Blood, 114, 5236-44. doi:10.1182/blood-2009-04-219204
  25. Involvement of CD44v6 in InIB-dependent Listeria invation.
    Jung, C.; Matzke, A.; Niemann, H. H.; Schwerk, C.; Tenenbaum, T.; Orian-Rousseau, V.
    2009. Molecular Microbiology, 72, 1196-1207. doi:10.1111/j.1365-2958.2009.06716.x
  26. Haploinsufficiency of c-Met in CD44-/- mice identifies a collaboration of CD44 and c-Met in vivo.
    Matzke, A.; Sargsyan, V.; Holtmann, B.; Aramuni, G.; Asan, E.; Sendtner, M.; Pace, G.; Howells, N.; Zhang, W.; Ponta, H.; Orian-Rousseau, V.
    2007. Molecular and Cellular Biology, 27, 8797-8806. doi:10.1128/MCB.01355-07
  27. Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin.
    Orian-Rousseau, V.; Morrison, H.; Matzke, A.; Kastilan, T.; Pace, G.; Herrlich, P.; Ponta, H.
    2007. Molecular Biology of the Cell, 18, 76-83. doi:10.1091/mbc.E06-08-0674
  28. A five-amino-acid peptide blocks Met- and Ron-dependent cell migration.
    Matzke, A.; Herrlich, P.; Ponta, H.; Orian-Rousseau, V.
    2005. Cancer Research, 65, 6105-10
  29. Genes upregulated in a metastasizing human colon carcinoma cell line.
    Orian-Rousseau, V.; Mink, S.; Mengwasser, J.; HogenEsch, H.; Guo, F.; Thies, W. G.; Hofmann, M.; Herrlich, P.; Ponta, H.
    2005. International Journal of Cancer, 113, 699-705. doi:10.1002/ijc.20644
  30. Aromatic amino acids at the surface of InlB are essential for host cell invasion by Listeria monocytogenes.
    Machner, M. P.; Frese, S.; Schubert, W. D.; Orian-Rousseau, V.; Gherardi, E.; Wehland, J.; Niemann, H. H.; Heinz, D. W.
    2003. Molecular Microbiology, 48, 1525-1536
  31. CD44 is required for two consecutive steps in HGF/c-Met signalling.
    Orian-Rousseau, V.; Chen, L.; Sleeman, J. P.; Herrlich, P.; Ponta, H.
    2002. Genes and Development, 16, 3074-86