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Biohybrid Nanoarrays for Biotechnological and Biomedical Applications


Group Leader: Guillaume Delaittre

tel.: +49 721 608 24476
fax: +49 721 608 24673
email: guillaume delaittrePkt2∂kit edu

Delaittre Lab Members
Delaittre Publications

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Our team is physically based at the KIT Campus North and funded by the German Ministry of Education and Research.  Our group is jointly hosted by the Institute of Toxicology and Genetics and the Institute of Chemical Technology and Polymer Chemistry, particularly in the group of Prof. Barner-Kowollik.
We aim at developing novel hybrid nanostructured surfaces and colloids by combining polymers and various biomolecules. We use organic chemistry (basic, modular ligations, photochemistry), modern techniques of macromolecular engineering (e.g., activation-deactivation radical polymerization, living ring-opening polymerization), modification of biomolecules (peptide synthesis, protein modification), and self-assembly principles to achieve our aims. We seek fundamental understanding or applications in the areas of protein-protein interaction, biocatalysis, and targeted delivery. Novel photochemical nanopatterning techniques are also among our interests. We work in close collaboration with other chemists but also with biologists, physicists, and engineers.
For a complete overview, please refer to the Publications section.



Our first “Vertieferstudent” starts today! Welcome Aaron!

We just went to the Karlsruher Christkindlesmarkt yesterday and had a nice time… we just forgot to immortalize this moment with a picture… next time!


As our group has grown significantly in the last months, we thought it was time for a new group picture! We chose this funny sculpture found at the entrance of our campus. Thanks to Elena, our official photographer!

Ziwei Zhang just joined us today to start her PhD. 欢迎 (huang yin’) Ziwei!

A new paper feeding the debate on dithiobenzoate-mediated RAFT polymerization from the Junkers group in Belgium with a contribution from Guillaume appeared online in Macromolecular Rapid Communications.

The PhD position that was published a few months ago has now been filled. Ms. Divya Varadharajan, who has been an assistant in the group for the last 2 months, will start her PhD next year… Great to have you stay with us Divya!

A study on the relevance of different SEC systems to characterize poly((meth)acrylic acid) carried out in 7 laboratories and led by Dr Igor Lacík (Polymer Institute, Slovak Academy of Sciences, Bratislava) yielded a manuscript that has just gone online in Macromolecular Chemistry and Physics. Thanks Igor!
Most experiments, for instance those from Guillaume with his former PhD supervisor Prof. Charleux, were carried out 8 years ago. Never give up!

The work of Jan Müller and Dominik Voll from the Barner-Kowollik group on fluorescent polymers, partly supervised by Guillaume, just appeared online in Chemical Communications. Thanks Jan and Dominik!

Gabriela Gil Alvaradejo finally arrived in Karlsruhe and starts today her PhD studies with us. Bienvenido and Willkommen Gabriela!

We have just been granted a YIN-Science Award for 2014. Oh yeah!
The YIN (Young Investigator Network) is the platform and democratic representation of interests for the junior research leaders of the KIT. We will receive 5000 Euros to help us start a new project on photoresponsive polymers, in collaboration with Dr Clemens Grabher.

Ms. Divya Varadharajan (MSc. Leipzig/Helsinki) just joined us today for 4 months. Welcome Divya!

A PhD position in chemistry (macromolecular, organic, and bioconjugate) with a start in January 2015 is available in the frame of the BMBF-funded program Molecular Interaction Engineering. You can find it in the Positions page!


Ms. Gabriel Gil Alvaradejo from Mexico City was just granted a CONACYT fellowship to join us as a PhD student in the next 3 years: “Felicidades” Gabriela and see you in October in Germany!

Hatice won the conference fee contest of the Biointerfaces International Graduate School (BIF-IGS) and will receive about 1000 Euros to travel to Sitges (Spain) next year for the 4th International Conference on Multifunctional, Hybrid and Nanomaterials. Congratulations Hatice!

Ms. Ziwei Zhang from China Pharmaceutical University in Nanjing has been awarded a CSC scholarship to work in our group: Congratulations Ziwei! She will join us later this autumn in Karlsruhe!

The work of Johannes Willenbacher from the Macroarc group on water-borne single-chain folding, with a contribution of Guillaume, is now available online in Chemical Communications!

Guillaume was invited to participate to the prestigious German-American Frontiers of Science Symposium (jointly organized by the Alexander von Humboldt Foundation and the Kavli Foundation) in Irvine (CA), USA. He enjoyed a lot exchanging ideas with scientists originating from a broad range of backgrounds (chemists of course, biologists, physicists, mathematicians, clinicians, linguists, and psychologists).

This is not a 1st of April joke!... Our first group picture has been taken and is now on our homepage!

The PhD student position that was advertised earlier has been filled! Dominic Keller will join us on the 3rd of March!
Nevertheless, there are still two positions remaining. We need two students for 4–6 months. We are looking preferably for 2nd year Master students but 1st year Master or students looking for a Vertiefungspraktikum or a Bachelor thesis are welcome to approach us!

It is recruiting time again! We are eagerly looking for a PhD candidate with a strong background in polymer and/or organic synthesis to work on Biohybrid Multifunctional Polymeric Assemblies as well as two Master students on topics entitled “Biological Signal Photoactivation via Responsive Polymers” and “Photopatterning of Polymer Strands”. A description of the positions can be found in the Positions section.

The postdoctoral position advertised in June has been filled! We are extremely happy to welcome Ana Beloqui Elizazu in the group. Ana will start in February.

The work of Benjamin Richter and Guillaume on the spatially resolved functionalization of 3D microscaffolds, carried out in the Bastmeyer and Barner-Kowollik groups, just appeared online in Advanced Materials!

The work on urea- and amide-containing monomers of Alexander Hähnel  from the Barner-Kowollik group with a contribution of Guillaume has been published online in Polymer Chemistry!

Hatice Turgut (MSc Bilkent University, Ankara, Turkey) starts as the first PhD student of the group! Welcome Hatice!

A new postdoctoral position is available. The research topic will deal with protein modification, by either chemical biology protocols or direct chemical modification. The modified biomolecules will then be integrated into biohybrid polymeric scaffolds for a biotechnological purpose. The full description of this offer is visible in “Positions” page.

An essay written by Guillaume on the pathway to becoming an academic has been published today. Guillaume was invited by the editors of the Polymer Chemistry blog to share his experience and feelings on how to become an academic. While an RSC-reduced version appears on the blog, the full-length version can be read here.

A new article based on the work of Guillaume with his former colleagues of the Radboud University Nijmegen in the Netherlands has just been published in Journal of Materials Chemistry B!

KICK-OFF!!! The group is officially created!
We are seeking one PhD candidate to work on the topic of Polymeric Materials for Biotechnological Applications. The job offer is visible in the Positions section of the group website.




Last update: February 27, 2015