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Biohybrid Nanoarrays for Biotechnological and Biomedical Applications



Group Leader: Guillaume Delaittre

tel.: +49 721 608 24476
fax: +49 721 608 24673
email: guillaume.delaittre∂kit.edu




Delaittre Lab Members
Delaittre Publications

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Our team is physically based at the KIT Campus North and funded by the German Ministry of Education and Research.  Our group is jointly hosted by the Institute of Toxicology and Genetics and the Institute of Chemical Technology and Polymer Chemistry, particularly in the group of Prof. Barner-Kowollik.
We aim at developing novel hybrid nanostructured surfaces and colloids by combining polymers and various biomolecules. We use organic chemistry (basic, modular ligations, photochemistry), modern techniques of macromolecular engineering (e.g., activation-deactivation radical polymerization, living ring-opening polymerization), modification of biomolecules (peptide synthesis, protein modification), and self-assembly principles to achieve our aims. We seek fundamental understanding or applications in the areas of protein-protein interaction, biocatalysis, and targeted delivery. Novel photochemical nanopatterning techniques are also among our interests. We work in close collaboration with other chemists but also with biologists, physicists, and engineers.
For a complete overview, please refer to the Publications section.




Today: double whammy! Both Dominic and Gabriela just won an award of up to 1000 Euros at the conference fee contest of the Biointerfaces International Graduate School (BIF-IGS). This will help them travel to the Warwick Polymer Conference 2016 and the ACS Fall Meeting 2016, respectively. Herzlichen Glückwunsch an Dominic & felicidades a Gaby!


Congratulations to Gabriela who just received a full scholarship to attend the 1st International Forum of Mexican Talent in April in Guadalajara!


Tobias, who already performed his Vertiefungspraktikum with us last year, is back for his Master Thesis. Good to have you back, Tobias!


Some of us just attended the annual national polymer conference Makromolekulares Kolloquium in Freiburg. It was relatively quiet this year in terms of partying but the talks and posters were usually interesting!


Tanja’s paper on the use of new photoreactive monomers for 3D laser writing and the simultaneous orthogonal functionalization of the resulting structures just came online on the Angewandte Chemie website. Tanja is co-supervised by Guillaume and Christopher Barner-Kowollik and this works was done in collaboration with Martin Bastmeyer’s team at KIT. Herzlichen Glückwunsch, Tanja!


Guillaume and Tanja, as well as some more members of the Macroarc group, just came back from the MacroBeGe2016 conference organized by Guillaume, Christopher Barner-Kowollik, and Filip Du Prez. Very nice talks from all invited speakers and all PhD students and postdocs… and what a party! See the Pictures section…


Our second independent paper just appeared on the website of Small. In this study, Ana shows beautifully the potential of single-enzyme nanogels for patterned immobilization in rapid and mild conditions, leading to biocatalysts with enhanced stability. ¡Felicidades y muchas gracias Ana!


Our very first independent group paper is online in Chemistry – A European Journal. It deals with the orthogonal functionalization of block copolymers with thiols. Congratulations to Hatice!


Guillaume received a poster award at the 4th Nano Today Conference held in Dubai, UAE. Feels like being a PhD student again… kind of weird! But thanks to Prof. Jackie Ying, her organization team, and Elsevier! This poster dealt with Tanja’s work (photoreactive microstructures). He also gave a talk on Ana’s single-enzyme nanogels.


Our group went to the Karlsruher Christkindlmarkt (Christmas Market). Not that cold this year but still enjoyable with some blueberry hot wine (Heidelbeer-Glühwein) and greasy food! And we did not forget to take a picture this time!


Guillaume acted for the first time as a main referee (rapporteur) of a PhD thesis, and this in France! Thanks to the colleagues of Marseille for their trust. It was fun… especially the football game on Sunday evening!


Guillaume just finished his conference tour after 8 days in Japan. He attended the APME2015 conference in Yokohama where he orally presented the work of Ana on enzyme encapsulation and had two posters on the studies of Hatice (orthogonal thiol-based chemistries) and Tanja (photoreactive 3D microstructures). This was followed by some sightseeing in Yokohama, Kamakura, and Tokyo. His impressions: extremely friendly and respectful people, great food (Tuna!!! Noodles!!! Yakiniku!!! Whiskies!!!), and fascinating cities and historical sites.
Before that, he also attended the Kármán conference, a very high-level – yet intimate – symposium in Vaals (Netherlands) organized by Prof. Martin Moeller (DWI-Leibniz Aachen). He presented the work of Ana with a poster on the encapsulation of enzymes.

The group participated to the annual excursion of the ITG in the region of Rhodt and Rietburg in the beautiful wine region of Palatinate. We spent a nice day with hiking in the rain to the Rietburg castle, visiting the Villa Ludwigshöhe, enjoying a nice lunch with the finest German specialties (Spätzle and Leberknödel), and attending a wine tour/tasting at the Gries winery. Despite the terrible weather, it was fun! Visit our Pictures section.

Guillaume is just back from the 6th Brazilian-German Frontiers of Science and Technology Symposium 2015, where he organized a session entitled “New engineering technologies for future medicines”, together with Brazilian colleagues Rodrigo Stabeli and Daniella Arêas Mendes-da-Cruz (Oswaldo Cruz Foundation, Fiocruz). Lots of interesting people and future collaborations ahead!

We just took a new group picture in the beautiful front courtyard of the Education Center for Forest and Environment of Karlsruhe (Forstliches Bildungszentrum Karlsruhe). Once more: Thanks Elena!

Aaron, who was our first Vertiefungspraktikum student, comes back as our first Master student. Welcome back Aaron!

Hatice won the first prize for the best talk at the annual retreat of the BioInterfaces Internal Graduate School! Great job Hatice!

Welcome to our 2nd Vertieferstudent Tobias Nitsche, who will work with Dominic on ring-opening polymerization.

We had the visit of a very old man today in the lab… Karl Wilhelm III! He is the founder of the city of Karlsruhe, which celebrates its 300th anniversary this year. This visit was part of the itinerary of the Margrave’s replica and is linked to the current exhibition “Karl Wilhelm 1679-1738” at the Badisches Landesmuseum.

If you want to know more about the importance of cycloaddition protocols in the synthesis of polymeric materials, a review co-written with Nathalie Guimard (an ex KIT colleague) and Christopher Barner-Kowollik just made it online at Accounts of Chemical Research!

New Advanced Materials article online! Co-supervised by Guillaume, the work of Astrid from the Macroarc group was done in collaboration with the group of Steffen Scholpp, also at the ITG.

Divya starts her PhD today! Welcome back!

Our first “Vertieferstudent” starts today! Welcome Aaron!

We just went to the Karlsruher Christkindlesmarkt yesterday and had a nice time… we just forgot to immortalize this moment with a picture… next time!

As our group has grown significantly in the last months, we thought it was time for a new group picture! We chose this funny sculpture found at the entrance of our campus. Thanks to Elena, our official photographer!

Ziwei Zhang just joined us today to start her PhD. 欢迎 (huang yin’) Ziwei!

A new paper feeding the debate on dithiobenzoate-mediated RAFT polymerization from the Junkers group in Belgium with a contribution from Guillaume appeared online in Macromolecular Rapid Communications.

The PhD position that was published a few months ago has now been filled. Ms. Divya Varadharajan, who has been an assistant in the group for the last 2 months, will start her PhD next year… Great to have you stay with us Divya!

A study on the relevance of different SEC systems to characterize poly((meth)acrylic acid) carried out in 7 laboratories and led by Dr Igor Lacík (Polymer Institute, Slovak Academy of Sciences, Bratislava) yielded a manuscript that has just gone online in Macromolecular Chemistry and Physics. Thanks Igor!
Most experiments, for instance those from Guillaume with his former PhD supervisor Prof. Charleux, were carried out 8 years ago. Never give up!

The work of Jan Müller and Dominik Voll from the Barner-Kowollik group on fluorescent polymers, partly supervised by Guillaume, just appeared online in Chemical Communications. Thanks Jan and Dominik!

Gabriela Gil Alvaradejo finally arrived in Karlsruhe and starts today her PhD studies with us. Bienvenido and Willkommen Gabriela!

We have just been granted a YIN-Science Award for 2014. Oh yeah!
The YIN (Young Investigator Network) is the platform and democratic representation of interests for the junior research leaders of the KIT. We will receive 5000 Euros to help us start a new project on photoresponsive polymers, in collaboration with Dr Clemens Grabher.

Ms. Divya Varadharajan (MSc. Leipzig/Helsinki) just joined us today for 4 months. Welcome Divya!

A PhD position in chemistry (macromolecular, organic, and bioconjugate) with a start in January 2015 is available in the frame of the BMBF-funded program Molecular Interaction Engineering. You can find it in the Positions page!


Ms. Gabriel Gil Alvaradejo from Mexico City was just granted a CONACYT fellowship to join us as a PhD student in the next 3 years: “Felicidades” Gabriela and see you in October in Germany!

Hatice won the conference fee contest of the Biointerfaces International Graduate School (BIF-IGS) and will receive about 1000 Euros to travel to Sitges (Spain) next year for the 4th International Conference on Multifunctional, Hybrid and Nanomaterials. Congratulations Hatice!

Ms. Ziwei Zhang from China Pharmaceutical University in Nanjing has been awarded a CSC scholarship to work in our group: Congratulations Ziwei! She will join us later this autumn in Karlsruhe!

The work of Johannes Willenbacher from the Macroarc group on water-borne single-chain folding, with a contribution of Guillaume, is now available online in Chemical Communications!

Guillaume was invited to participate to the prestigious German-American Frontiers of Science Symposium (jointly organized by the Alexander von Humboldt Foundation and the Kavli Foundation) in Irvine (CA), USA. He enjoyed a lot exchanging ideas with scientists originating from a broad range of backgrounds (chemists of course, biologists, physicists, mathematicians, clinicians, linguists, and psychologists).

This is not a 1st of April joke!... Our first group picture has been taken and is now on our homepage!

The PhD student position that was advertised earlier has been filled! Dominic Keller will join us on the 3rd of March!
Nevertheless, there are still two positions remaining. We need two students for 4–6 months. We are looking preferably for 2nd year Master students but 1st year Master or students looking for a Vertiefungspraktikum or a Bachelor thesis are welcome to approach us!

It is recruiting time again! We are eagerly looking for a PhD candidate with a strong background in polymer and/or organic synthesis to work on Biohybrid Multifunctional Polymeric Assemblies as well as two Master students on topics entitled “Biological Signal Photoactivation via Responsive Polymers” and “Photopatterning of Polymer Strands”. A description of the positions can be found in the Positions section.

The postdoctoral position advertised in June has been filled! We are extremely happy to welcome Ana Beloqui Elizazu in the group. Ana will start in February.

The work of Benjamin Richter and Guillaume on the spatially resolved functionalization of 3D microscaffolds, carried out in the Bastmeyer and Barner-Kowollik groups, just appeared online in Advanced Materials!

The work on urea- and amide-containing monomers of Alexander Hähnel  from the Barner-Kowollik group with a contribution of Guillaume has been published online in Polymer Chemistry!

Hatice Turgut (MSc Bilkent University, Ankara, Turkey) starts as the first PhD student of the group! Welcome Hatice!

A new postdoctoral position is available. The research topic will deal with protein modification, by either chemical biology protocols or direct chemical modification. The modified biomolecules will then be integrated into biohybrid polymeric scaffolds for a biotechnological purpose. The full description of this offer is visible in “Positions” page.

An essay written by Guillaume on the pathway to becoming an academic has been published today. Guillaume was invited by the editors of the Polymer Chemistry blog to share his experience and feelings on how to become an academic. While an RSC-reduced version appears on the blog, the full-length version can be read here.

A new article based on the work of Guillaume with his former colleagues of the Radboud University Nijmegen in the Netherlands has just been published in Journal of Materials Chemistry B!

KICK-OFF!!! The group is officially created!
We are seeking one PhD candidate to work on the topic of Polymeric Materials for Biotechnological Applications. The job offer is visible in the Positions section of the group website.




Last update: April 06, 2016