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Christine Blattner - Publications


  1. PROTEOSTASIS: A European Network to Break Barriers and Integrate Science on Protein Homeostasis.
    Dissmeyer, N.; Coux, O.; Rodriguez, M. S.; Barrio, R.; Ballar, P.; Barrio, R.; Blattner, C.; Bomont, P.; Carracedo, A.; Clague, M. J.; Coux, O.; Dantuma, N.; Dissmeyer, N.; Farràs, R.; Girao, H.; Glickman, M.; Holmberg, C. I.; Jupin, I.
    2019. Trends in biochemical sciences, 44 (5), 383–387. doi:10.1016/j.tibs.2019.01.007
  2. Delay in development and behavioural abnormalities in the absence of p53 in zebrafish.
    Elabd, S.; Jabeen, N. A.; Gerber, V.; Peravali, R.; Bourdon, J.-C.; Kancherla, S.; Vallone, D.; Blattner, C.
    2019. PLOS ONE, 14 (7), Art.-Nr.: e0220069. doi:10.1371/journal.pone.0220069
  3. Fam83F induces p53 stabilisation and promotes its activity.
    Salama, M.; Benitez-Riquelme, D.; Elabd, S.; Munoz, L.; Zhang, P.; Glanemann, M.; Mione, M. C.; Goldin, R.; Soussi, T.; Davidson, G.; Blattner, C.
    2019. Cell death and differentiation, 26, 2125–2138. doi:10.1038/s41418-019-0281-1
  4. Amniotic Fluid Cells, Stem Cells, and p53: Can We Stereotype p53 Functions?.
    Rodrigues, M.; Blattner, C.; Stuppia, L.
    2019. International journal of molecular sciences, 20 (9), Article: 2236. doi:10.3390/ijms20092236
  5. The transient production of anti-TNF-α antibody Adalimumab and a comparison of its characterization to the biosimilar Cinorra.
    Tabasinezhad, M.; Mahboudi, F.; Wenzel, W.; Rahimi, H.; Walther, T. H.; Blattner, C.; Omidinia, E.
    2019. Protein expression and purification, 155, 59–65. doi:10.1016/j.pep.2018.11.006
  6. P53 is active in human amniotic fluid stem cells.
    Rodrigues, M.; Antonucci, I.; Elabd, S.; Kancherla, S.; Marchisio, M.; Blattner, C.; Stuppia, L.
    2018. Stem Cells and Development, 27 (21), 1507–1517. doi:10.1089/scd.2017.0254
  7. Tripartite Motif Proteins-A Protein Family Strongly Linked to Cancer.
    Elabd, S.; Cato, A. C. B.; Blattner, C.
    2017. Annals of Pharmacology and Pharmaceutics, 2 (10), 1–5
  8. TRIMming p53’s anticancer activity.
    Elabd, S.; Meroni, G.; Blattner, C.
    2016. Oncogene, 35 (43), 5577–5584. doi:10.1038/onc.2016.33
  9. Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth.
    Dewaele, M.; Tabaglio, T.; Willekens, K.; Bezzi, M.; Teo, S. X.; Low, D. H. P.; Koh, C. M.; Rambow, F.; Fiers, M.; Rogiers, A.; Radaelli, E.; Al-Haddawi, M.; Tan, S. Y.; Hermans, E.; Amant, F.; Yan, H.; Lakshmanan, M.; Koumar, R. C.; Lim, S. T.; Derheimer, F. A.; Campbell, R. M.; Bonday, Z.; Tergaonkar, V.; Shackleton, M.; Blattner, C.; Marine, J.-C.; Guccione, E.
    2016. Journal of Clinical Investigation, 126 (1), 68–84. doi:10.1172/JCI82534
  10. Expression screening using a Medaka cDNA library identifies evolutionarily conserved regulators of the p53/Mdm2 pathway.
    Zhang, P.; Kratz, A. S.; Salama, M.; Elabd, S.; Heinrich, T.; Wittbrodt, J.; Blattner, C.; Davidson, G.
    2015. BMC Biotechnology, 15 (1), 92. doi:10.1186/s12896-015-0208-y
  11. New tricks for p53 regulation - restraint by protein coding RNAs.
    Blattner, C.
    2015. Cell and Bioscience, 5 (1), 30. doi:10.1186/s13578-015-0022-1
  12. P53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53.
    Yan, H.; Solozobova, V.; Zhang, P.; Armant, O.; Kuehl, B.; Brenner-Weiss, G.; Blattner, C.
    2015. Cell Death and Disease, 6 (2), e1662/1–11. doi:10.1038/cddis.2015.33
  13. TRIM25 has a dual function in the p53/Mdm2 circuit.
    Zhang, P.; Elabd, S.; Hammer, S.; Solozobova, V.; Yan, H.; Bartel, F.; Inoue, S.; Henrich, T.; Wittbrodt, J.; Loosli, F.; Davidson, G.; Blattner, C.
    2015. Oncogene, 34, 5729–5738. doi:10.1038/onc.2015.21
  14. The estrogen-inducible finger-protein TRIM25 controls p53 abundance and activity.
    Zhang, P.; Blattner, C.
    2015. The Biochemical Basis of Life : 40th FEBS Congress, Berlin, July 4-9, 2015 FEBS Journal, 282(2015) Suppl.1, (Abstract)
  15. Hierarchical micro-nano surface topography promotes long-term maintenance of undifferentiated mouse embryonic stem cells.
    Jaggy, M.; Zhang, P.; Greiner, A. M.; Autenrieth, T. J.; Nedashkivska, V.; Efremov, A. N.; Blattner, C.; Bastmeyer, M.; Levkin, P. A.
    2015. Nano letters, 15 (10), 7146–7154. doi:10.1021/acs.nanolett.5b03359
  16. Tetramerization-defects of p53 result in aberrant ubiquitylation nd transcriptional activity.
    Lang, V.; Pallara, C.; Zabala, A.; Lobato-Gil, S.; Lopitz-Otsoa, F.; Farras, R.; Hjerpe, R.; Torres-Ramos, M.; Zabaleta, L.; Blattner, C.; Hay, R. T.; Barrio, R.; Carracedo, A.; Fernandez-Recio, J.; Rodriguez, M. S.; Aillet, F.
    2014. Molecular oncology, 8, 1026–1042. doi:10.1016/j.molonc.2014.04.002
  17. Interaction of HPV E6 oncoproteins with specific proteasomal subunits.
    Tomaic, V.; Ganti, K.; Pim, D.; Bauer, C.; Blattner, C.; Banks, L.
    2013. Virology, 446, 389–396. doi:10.1016/j.virol.2013.08.016
  18. Meeting report: signal transduction meets systems biology.
    Louis-Dit-Sully, C.; Kubatzky, K. F.; Lindquist, J. A.; Blattner, C.; Janssen, O.; Schamel, W. A.
    2012. Cell Communication and Signaling, 10, 11. doi:10.1186/1478-811X-10-11
  19. Regulation of p53: Size matters. Comment on: Dolezelova P, et al. Cell Cycle 2012; 11:953-62.
    Blattner, C.
    2012. Cell Cycle, 11, 1269–1270. doi:10.4161/cc.19903
  20. PCNA-dependent accumulation of CDKN1A into nuclear foci after ionizing irradiation.
    Wiese, C.; Rudolph, J. H.; Jakob, B.; Fink, D.; Tobias, F.; Blattner, C.; Taucher-Scholz, G.
    2012. DNA Repair, 11, 511–521. doi:10.1016/j.dnarep.2012.02.006
  21. LiCl induces TNF-α and FasL production, thereby stimulating apoptosis in cancer cells.
    Kaufmann, L.; Marinescu, G.; Nazarenko, I.; Thiele, W.; Oberle, C.; Sleeman, J.; Blattner, C.
    2011. Cell Communication and Signaling, 9, 15. doi:10.1186/1478-811X-9-15
  22. DNA Repair in Embryonic Stem Cells.
    Middel, V.; Blattner, C.
    2011. DNA Repair - On the Pathways to Fixing DNA Damage and Errors. Ed.: F. Storici, 357–380, InTech, Rijeka. doi:10.5772/23498
  23. p53 in stem cells.
    Solozobova, V.; Blattner, C.
    2011. World Journal of Biological Chemistry, 2, 202–214. doi:10.4331/wjbc.v2.i9.202
  24. The E3 ligase Mdm2 ubiquitinates several proteins of the 19S regulatory complex of the proteasome.
    Letienne, J.; Blattner, C.
    2010. 14th Joint Meeting of the Signal Transduction Society (STS), Weimar, October 18-20, 2010
  25. Regulation of p53 in embryonic stem cells.
    Solozobova, V.; Blattner, C.
    2010. Experimental Cell Research, 316, 2434–46. doi:10.1016/j.yexcr.2010.06.006
  26. Mdm2 facilitates the association of p53 with the proteasome.
    Kulikov, R.; Letienne, J.; Kaur, M.; Grossman, S. R.; Arts, J.; Blattner, C.
    2010. Proceedings of the National Academy of Sciences of the United States of America, 107, 10038–10043. doi:10.1073/pnas.0911716107
  27. Regulation of the tumor suppressor protein p53 in embryonic stem cells.
    Blattner, C.; Solozobova, V.
    2010. Stem Cells, Tissue Homeostasis and Cancer, EMBL Heidelberg, May 12-15, 2010
  28. Regulation of the DNA damage response to DSBs by post-translational modifications.
    Oberle, C.; Blattner, C.
    2010. Current Genomics, 11, 184–98. doi:10.2174/138920210791110979
  29. Regulation of p53 activity.
    Boehme, K. A.; Blattner, C.
    2010. Current Chemical Biology, 4, 1–12. doi:10.2174/187231310790226242
  30. Regulation of p53 - insights into a complex process.
    Boehme, K. A.; Blattner, C.
    2009. Critical Reviews in Biochemistry ad Molecular Biology, 44, 367–92. doi:10.3109/10409230903401507
  31. Regulation of abundance, localisation and activity of DNA repair factors by post-translational modification.
    Blattner, C.
    2009. 12.Jahrestagung der Gesellschaft für Biologische Strahlenforschung (GBS), Essen, 30.September - 2.Oktober 2009
  32. p53 - ein Tumorsuppressor-Protein zwischen Krebsentstehung und Therapie.
    Blattner, C.
    2009. Deutsche Zeitschrift für klinische Forschung, (2009) /10, (9), 30–36
  33. Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage.
    Solozobova, V.; Rolletschek, A.; Blattner, C.
    2009. BMC Cell Biology, 10:46, 10. doi:10.1186/1471-2121-10-46
  34. ’Junk’ DNA meets the p53 network.
    Blattner, C.
    2008. Molecular Systems Biology, 4 (231). doi:10.1038/msb.2008.68
  35. Regulation of p53: The next generation.
    Blattner, C.
    2008. Cell Cycle, 7, 3149–53
  36. MDMX promotes proteasomal turnover of p21 at G₁ and early S phases independently of, but in cooperation with, MDM2.
    Jin, Y.; Zeng, S. X.; Sun, X. X.; Lee, H.; Blattner, C.; Xiao, Z.; Lu, H.
    2008. Molecular and Cellular Biology, 28, 1218–29. doi:10.1128/MCB.01198-07
  37. Nucleotide excision repair driven by the dissociation of CAK from TFIIH.
    Coin, F.; Oksenych, V.; Mocquet, V.; Groh, S.; Blattner, C.; Egly, J. M.
    2008. Molecular Cell, 31, 9–20. doi:10.1016/j.molcel.2008.04.024
  38. p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.
    Boehme, K. A.; Kulikov, R.; Blattner, C.
    2008. Proceedings of the National Acdemy of Sciences of the United States of America, 105, 7785–90. doi:10.1073/pnas.0703423105
  39. Post-translational modifications of Mdm2 and their implication for p53 degradation.
    Kulikov, R.; Kaur, R.; Chan, Y.; Grossman, S.; Arts, J.; Blattner, C.
    2007. Internat. MDM2 Workshop IV, Woods Hole, Mass., September 30 - October 3, 2007
  40. The ubiquitin ligase MDM2 links P53 to the 19S regulatory subunit of the proteasome.
    Kulikov, R.; Kaur, M.; Chan, Y.; Grossmann, S.; Blattner, C.
    2007. 2nd Meeting of the Intracellular Proteolysis Network : Recipie/Inproteolys, Valencia, E, March 7-9, 2007
  41. It’s not all ATM - GSK-3, Akt/PKB and DNA-PK contribute to the stabilization of p53 in response to ionising radiation.
    Boehme, K. A.; Kulikov, R.; Blattner, C.
    2006. Signal Transduction : Receptors, Mediators and Genes, 2006 Meeting of the Signal Transduction Society (STS), Weimar, November 2-4, 2006
  42. Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation.
    Kulikov, R.; Winter, M.; Blattner, C.
    2006. Journal of Biological Chemistry, 281, 28575–83. doi:10.1074/jbc.M513311200
  43. Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance.
    Kulikov, R.; Boehme, K. A.; Blattner, C.
    2005. Molecular and Cellular Biology, 25, 7170–80. doi:10.1128/MCB.25.16.7170-7180.2005
  44. The ubiquitin ligase Mdm2 interacts with the 19S regulatory subunit of the proteasome.
    Kulikov, R.; Kaur, M.; Chan, Y.; Grossman, S.; Blattner, C.
    2005. 3rd Internat.Mdm2 Workshop, Konstanz, September 9-12, 2005
  45. Interactions of the Mdm2 protein with the proteasome as a potential requirement for the degradation of the tumor suppressor protein p53.
    Blattner, C.; Kaur, M.; Chan, Y.; Grossman, S.; Kulikov, R.
    2005. 3rd Internat.Mdm2 Workshop, Konstanz, September 9-12, 2005
  46. Protein Kinase CK1δ Phosphorylates Key Sites in the Acidic Domain of Murine Double-Minute Clone 2 Protein (MDM2) That Regulate p53 Turnover.
    Winter, M.; Milne, D.; Dias, S.; Kulikov, R.; Knippschild, U.; Blattner, C.; Meek, D.
    2004. Biochemistry, (2004), 43 (51), 16356–16364. doi:10.1021/bi0489255
  47. The basal transcription factor IIH dissociates in response to UV-irradiation.
    Groh, S.; Blattner, C.
    2004. 8.DNA Repair Workshop, Ulm, September 28 - October 1, 2004
  48. Regulation of p53 in response to ionizing radiation.
    Kulikov, R.; Blattner, C.
    2004. 33rd Annual Meeting of the European Society for Radiation Biology, Budapest, H, August 25-28, 2004
  49. Inhibition of glykogen-synthase-kinase-3 contributes to the increase in p53 stability after ionizing irradiation.
    Kulikov, R.; Blattner, C.
    2004. 8th Internat.Wolfsberg Meeting on Molecular Radiation Biology/Oncology, Ermatingen, CH, June 26-28, 2004
  50. Einfluss der Glykogen-Synthase-Kinase-3 auf das Tumorsuppressorprotein p53 nach ionisierender Strahlung.
    Kulikov, R.; Blattner, C.
    2004. 7.Jahrestagung der Gesellschaft für Biologische Strahlenforschung (GBS), Darmstadt, 31.März - 2.April 2004
  51. P53 stabilization and the role of radiation-induced signalling.
    Blattner, C.; Winter, M.; Kulikov, R.
    2004. Kiefer, J. [Hrsg.] Life Sciences and Radiation : Accomplishments and Future Directions ; Internat.Workshop, Giessen, October 3-7, 2002 Berlin [u.a.] : Springer, 2004
  52. P53 stabilization and the role of radiation-induced signalling.
    Blattner, C.; Winter, M.; Kulikov, R.
    2004. Kiefer, J. [Hrsg.] Life Sciences and Radiation : Accomplishments and Future Directions ; Internat.Workshop, Giessen, October 3-7, 2002 Berlin [u.a.] : Springer, 2004, 93–99
  53. Regulation des Tumorsuppressor Proteins p53 nach Bestrahlung. habilitation thesis.
    Blattner, C.
    2003. Universität Karlsruhe, Karlsruhe
  54. Involvement of the DNA repair protein hHR23 in p53 degradation.
    Glockzin, S.; Ogi, F. X.; Hengstermann, A.; Scheffner, M.; Blattner, C.
    2003. Molecular and Cellular Biology, 23, 8960–69. doi:10.1128/MCB.23.24.8960-8969.2003
  55. Radiation-induced cytoplasmic signaling.
    Blattner, C.; Herrlich, P.
    2003. Bradshaw, R. [Hrsg.] Handbook of Cell Signaling Vol.3 Amsterdam [u.a.] : Elsevier, 2003, 257–62
  56. GSK-3 regulates p53 stability.
    Blattner, C.; Kulikov, R.
    2003. 2nd Internat.Mdm2 Workshop, Washington, D.C., October 18-20, 2003
  57. GSK3-β wird durch ionisierende Strahlung inaktiviert. Einfluss auf die Stabilität des Tumorsupressorproteins p53.
    Kulikov, R.; Blattner, C.
    2003. 7th Wolfsberg Meeting ’Molecular Radiation Biology/Oncology, Ermatingen, CH, May 24-25, 2003
  58. HRad23 is required for p53 degradation.
    Ogi, F.; Glockzin, S.; Hengstermann, A.; Scheffner, M.; Blattner, C.
    2003. 11th Internat.p53 Workshop, Memorial Sloan-Kettering Cancer Center, New York, N.Y., May 15-19, 2002 Cold Spring Harbor Meeting on Cancer Genetics and Tumor Suppressor Genes, Cold Spring Harbor, N.Y., August 14-18, 2002 5th Workshop on Proteasomes, Clermont-Ferrand, F, April 27-29, 2003
  59. Hypophosphorylation of Mdm2 augments p53 stability.
    Blattner, C.; Hay, T.; Meek, D. V.; Lane, D. P.
    2002. Molecular and Cellular Biology, 22, 6170–82
  60. p53 und die zelluläre Antwort auf DNA Schäden.
    Kulikov, R.; Döring, G.; Blattner, C.
    2002. 6.Jahrestagung der Gesellschaft für Biologische Strahlenforschung, Göttingen, 25.-27.September 2002
  61. Non-genomic and genomic signaling in the induction of apoptosis by toxic agents.
    Göttlicher, M.; Blattner, C.; Klöhn, P. C.; Krug, H. F.; Böhmer, F. D.; Herrlich, P.
    2001. Meeting on Apoptosis and Signal Transduction, Lyon, F, December 12, 2001
  62. Stabilization of p53 in response to DNA damage.
    Blattner, C.; Hay, T.; Meek, D.; Lane, D.
    2001. European Radiation Research (ERR 2001), Dresden, September 1-5, 2001
  63. A novel function of Mdm2 that is regulated by phosphorylation.
    Blattner, C.; Hay, T.; Meek, D.; Lane, D.
    2001. 1st Internat.Mdm2 Workshop, Dundee, GB, September 15-18, 2001
  64. A novel function of Mdm2 for p53 degradation that is regulated by phosphorylation.
    Blattner, C.; Hay, T.; Meek, D.; Lane, D.
    2001. 5th Beatson Internat.Cancer Conf., Glasgow, GB, July 15-18, 2001
  65. UV-induced stabilization of c-fos and other short-lived mRNAs.
    Blattner, C.; Kannouche, P.; Litfin, M.; Bender, K.; Rahmsdorf, H. J.; Angulo, J. F.; Herrlich, P.
    2000. Molecular and Cellular Biology, 20, 3616–25
  66. Cell signalling and stress responses.
    Klöhn, P. C.; Göttlicher, M.; Knebel, A.; Boehmer, F.; Krug, H.; Blattner, C.; Herrlich, P.
    2000. DMW/ISSX 2000 Conf., St.Andrews, GB, June 11-16, 2000
  67. Signal transduction induced by adverse agents: ’activation by inhibition’. The UV response 1997.
    Herrlich, P.; Rahmsdorf, H. J.; Bender, K.; Blattner, C.; Knebel, A.
    1999. Puga, A. [Hrsg.] Molecular Biology of the Toxic Response Philadelphia, Pa. : Taylor and Francis, 1999, 479–92
  68. DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation.
    Blattner, C.; Tobiasch, E.; Litfen, M.; Rahmsdorf, H. J.; Herrlich, P.
    1999. Oncogene, 18, 1723–32
  69. Radiation-induced signal transduction. Mechanisms and consequences.
    Herrlich, P.; Bender, K.; Knebel, A.; Böhmer, F. D.; Gross, S.; Blattner, C.; Rahmsdorf, H. J.; Göttlicher, M.
    1999. Comptes Rendus de l’Academie de Sciences Paris, Ser.III, 322, 121–25